Original papers
Yutaro Ando, Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Shizao Zang, Minglu Yan, Ryunosuke Muro, Kazutaka Nakamura, Masatsugu Komagamine, Noriko Komatsu, Kazuo Okamoto, Kenta Nakano, Tadashi Okamura, Akira Yamaguchi, Kazuyuki Ishihara, Hiroshi Takayanagi
The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis
International Journal of Oral Science. 16:18, 2024
Masatsugu Komagamine, Noriko Komatsu, Rui Ling, Kazuo Okamoto, Shi Tianshu, Kotaro Matsuda, Tsutomu Takeuchi, Yuko Kaneko and Hiroshi Takayanagi
Effect of JAK inhibitors on the three forms of bone damage in autoimmune arthritis: joint erosion, periarticular osteopenia, and systemic bone loss.
Inflammation and Regeneration. 43:44, 2023
Minglu Yan, Tsukasaki Masayuki, Ryunosuke Muro, Noriko Komatsu, Takeshi Nitta, Tadashi Okamura, Kazuo Okamoto, Yutaro Ando, and Kazutaka Nakamura Hiroshi Takayanagi
Identification of an intronic enhancer regulating RANKL expression in osteocytic cells
Bone Research, 11: 43, 2023
Minglu Yan, Noriko Komatsu, Ryunosuke Muro, Nam Huynh, Yoshihiko Tomofuji, Yukinori Okada, Hiroshi Suzuki, Hiroyuki Takaba, Riko Kitazawa, Sohei Kitazawa, Warunee Pluemsakunthai, Yuichi Mitsui, Takashi Satoh, Tadashi Okamura, Takeshi Nitta, Sin-Hyeog Im, Chan Johng Kim, George Kollias, Sakae Tanaka, Kazuo Okamoto, Masayuki Tsukasaki and Hiroshi Takayanagi.
ETS1 governs pathological tissue remodeling programs in disease-associated fibroblasts
Nature Immunology, 23: 1330-1341, 2022.
Takehito Ono, Ryosuke Denda, Yuta Tsukahara, Takashi Nakamura, Kazuo Okamoto, Hiroshi Takayanagi and Tomoki Nakashima.
Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1a signaling
Bone Research. 10:52. 2022.
Masayuki Tsukasaki, Noriko Komatsu, Takako Negishi-Koga, Nam Cong-Nhat Huynh, Ryunosuke Muro, Yutaro Ando, Yuka Seki, Asuka Terashima, Warunee Pluemsakunthai, Takeshi Nitta, Takashi Nakamura, Tomoki Nakashima, Shinsuke Ohba, Haruhiko Akiyama, Kazuo Okamoto, Roland Baron and Hiroshi Takayanagi.
Periosteal stem cells control growth plate stem cells during postnatal skeletal growth
Nature Communications, 13: 4166, 2022
Mikhail M Kostik, Maria A Makhova, Alexei S Maletin, Shamai M Magomedova, Lybov S Sorokina, Masayuki Tsukasaki, Kazuo Okamoto, Hiroshi Takayanagi, Dmitriy S Vasiliev, Darya I Kozlova, Alexander Yu Mushkin.
Cytokine profile in patients with chronic non-bacterial osteomyelitis, juvenile idiopathic arthritis, and insulin-dependent diabetes mellitus
Cytokine, 143: 155521, 2021
Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Kazuo Okamoto, Ryunosuke Muro, Asuka Terashima, Yoshitaka Kurikawa, Noriko Komatsu, Warunee Pluemsakunthai, Takeshi Nitta, Takaya Abe, Hiroshi Kiyonari, Tadashi Okamura, Mashito Sakai, Toshiya Matsukawa, Michihiro Matsumoto, Yasuhiro Kobayashi, Josef M. Penninger and Hiroshi Takayanagi
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution
Nature Metabolism, 2: 1382-1390, 2020
Masayuki Tsukasaki, Tatsuo Asano, Ryunosuke Muro, Nam Cong-Nhat Huynh, Noriko Komatsu, Kazuo Okamoto, Kenta Nakano, Tadashi Okamura, Takeshi Nitta and Hiroshi Takayanagi
OPG production matters where it happened
Cell Reports, 32: 108124, 2020
Tatsuo Asano, Kazuo Okamoto*, Yuta Nakai, Masanori Tsutsumi, Ryunosuke Muro, Ayako Suematsu, Kyoko Hashimoto, Tadashi Okamura, Shogo Ehata, Takeshi Nitta and Hiroshi Takayanagi* (*: corresponding authors)
Soluble RANKL is physiologically dispensable but accelerates tumor metastasis to bone.
Nature Metabolism, 1: 868-875, 2019
Mikihito Hayashi, Tomoki Nakashima, Noriko Yoshimura, Kazuo Okamoto, Sakae Tanaka and Hiroshi Takayanagi
Autoregulation of osteocyte Sema3A orchestrates estrogen action and counteracts bone aging
Cell Metabolism, 29: 1-11, 2019
Yuta Nakai, Kazuo Okamoto*, Asuka Terashima, Shogo Ehata, Jun Nishida, Takeshi Imamura, Takashi Ono and Hiroshi Takayanagi* (*: corresponding authors)
Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis
Bone Research, 7: 1, 2019
Maia Inoue, Kazuo Okamoto, Asuka Terashima, Takeshi Nitta, Ryunosuke Muro, Takako Negishi-Koga, Toshio Kitamura, Tomoki Nakashima, and Hiroshi Takayanagi
Arginine methylation controls the strength of γc family cytokine signaling in T cell maintenance
Nature Immunology, 19: 1265-1276, 2018
Masayuki Tsukasaki, Noriko Komatsu, Kazuki Nagashima, Takeshi Nitta, Warunee Pluemsakunthai, Chisa Shukunami, Yoichiro Iwakura, Tomoki Nakashima, Kazuo Okamoto, and Hiroshi Takayanagi
Host defense against oral microbiota by bone-damaging T cells
Nature Communications, 9: 701, 2018
Masayuki Tsukasaki*, Koki Hamada*, Kazuo Okamoto, Kazuki Nagashima, Asuka Terashima, Noriko Komatsu, Stephanie Win, Tadashi Okamura, Takeshi Nitta, Hisataka Yasuda, Josef M. Penninger and Hiroshi Takayanagi *equally contributed
LOX fails to substitute for RANKL in osteoclastogenesis
Journal of Bone and Mineral Research, 32: 434-439, 2017
Asuka Terashima, Kazuo Okamoto, Tomoki Nakashima, Shizuo Akira, Koichi Ikuta and Hiroshi Takayanagi
Sepsis-induced osteoblast ablation causes immunodeficiency
Immunity, 44: 1434-43, 2016
Takehito Ono, Kazuo Okamoto, Tomoki Nakashima, Takeshi Nitta, Shohei Hori, Yoichiro Iwakura and Hiroshi Takayanagi
IL-17-producing γδT cells enhance bone regeneration
Nature Communications, 7: 10928, 2016
Matteo M. Guerrini, Kazuo Okamoto, Noriko Komatsu, Shinichiro Sawa, Lynett Danks, Josef M. Penninger, Tomoki Nakashima and Hiroshi Takayanagi
Inhibition of the TNF family cytokine RANKL prevents autoimmune inflammation in the central nervous system
Immunity, 43: 1174-85, 2015
Takako Negishi-Koga, Hans-Jürgen Gober, Eriko Sumiya, Noriko Komatsu, Kazuo Okamoto, Shinichiro Sawa, Ayako Suematsu, Tomomi Suda, Kojiro Sato, Toshiyuki Takai and Hiroshi Takayanagi
Immune complexes regulate bone metabolism through FcRg signaling
Nature Communications, 6: 6637, 2015
Yasunori Omata, Tetsuro Yasui, Jun Hirose, Naohiro Izawa, Yuuki Imai, Takumi Matsumoto, Hironari Masuda, Naoto Tokuyama, Shuichi Tsutsumi, Takanori Fujita, Hisataka Yasuda, Kazuo Okamoto, Hiroshi Takayanagi, Atsuhiko Hikita, Takeshi Imamura, Koichi Matsuo, Taku Saito, Yuho Kadono, Hiroyuki Aburatani, and Sakae Tanaka
Genome-wide comprehensive analysis reveals critical cooperation between Smad and c-Fos in RANKL-induced osteoclastogenesis
Journal of Bone and Mineral Research, 30:869-877, 2015
Noriko Komatsu, Kazuo Okamoto, Shinichiro Sawa, Tomoki Nakashima, Masatsugu Oh-hora, Tatsuhiko Kodama, Sakae Tanaka, Jeffrey A. Bluestone and Hiroshi Takayanagi
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
Nature Medicine, 20: 62-68,2014
Jun-ichi Furusawa, Kazuyo Moro, Yasutaka Motomura, Kazuo Okamoto, Jinfang Zhu, Hiroshi Takayanagi, Masato Kubo and Shigeo Koyasu
Critical Role of p38 and GATA3 in Natural Helper Cell Function.
The Journal of Immunology, 191: 1818-26, 2013
Erik Idrus, Tomoki Nakashima, Ling Wang, Mikihito Hayashi, Kazuo Okamoto, Tatsuhiko Kodama, Nobuyuki Tanaka, Tadatsugu Taniguchi and Hiroshi Takayanagi
The Role of the BH3-only Protein Noxa in Bone Homeostasis
Biochemical and Biophysical Research Communications, 410: 620-625, 2011
Kazuo Okamoto, Yoshiko Iwai, Masatsugu Oh-hora, Masahiro Yamamoto, Tomohiro Morio, Kazuhiro Aoki, Keiichi Ohya, Anton M. Jetten, Shizuo Akira, Tatsushi Muta and Hiroshi Takayanagi
IκBζ regulates TH17 development by cooperating with ROR nuclear receptors
Nature, 464: 1381-1385, 2010
Masahiro Shinohara, Takako Koga, Kazuo Okamoto, Shinya Sakaguchi, Kimiko Arai, Hisataka Yasuda, Toshiyuki Takai, Tatsuhiko Kodama, Tomohiro Morio, Raif S. Geha, Daisuke Kitamura, Tomohiro Kurosaki, Wilfried Ellmeier and Hiroshi Takayanagi
Tyrosine Kinases Btk and Tec Regulate Osteoclast Differentiation by Linking RANK and ITAM Signals
Cell, 132: 794-806, 2008
Masataka Asagiri, Toshitake Hirai, Toshihiro Kunigami, Shunya Kamano, Hans-Jürgen Gober, Kazuo Okamoto, Keizo Nishikawa, Eicke Latz, Douglas T. Golenbock, Kazuhiro Aoki, Keiichi Ohya, Yuuki Imai, Yasuyuki Morishita, Kohei Miyazono, Shigeaki Kato, Paul Saftig and Hiroshi Takayanagi
Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis
Science, 319: 624-627, 2008
Kojiro Sato, Ayako Suematsu, Kazuo Okamoto, Akira Yamaguchi, Yasuyuki Morishita, Yuho Kadono, Sakae Tanaka, Tatsuhiko Kodama, Shizuo Akira, Yoichiro Iwakura, Daniel J. Cua and Hiroshi Takayanagi
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
Journal of Experimental Medicine 203: 2673-2682, 2006
Takuya Yamamoto, Miki Ebisuya, Fumito Ashida, Kazuo Okamoto, Shin Yonehara and Eisuke Nishida
Continuous ERK Activation Downregulates Anti-proliferative Genes throughout G1 Phase to Allow Cell Cycle Progression
Current Biology, 16: 1171-1182, 2006
Kazuo Okamoto, Jun-ichi Fujisawa, Michael Reth and Shin Yonehara
Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kB
Genes to Cells, 11: 177-191, 2006
Kozo Watanabe, Kazuo Okamoto and Shin Yonehara
Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP
Cell Death and Differentiation, 12: 10-18, 2005
Reviews
Kazuo Okamoto
Crosstalk between bone and the immune system
Journal of Bone and Mineral Metabolism, 2024
https://doi.org/10.1007/s00774-024-01539-x
Kazuo Okamoto* and Hiroshi Takayanagi (*: corresponding authors)
Effect of T cells on bone
Bone. 168:116675, 2023.
Kazuo Okamoto
Role of RANKL in cancer development and metastasis
Journal of Bone and Mineral Metabolism, 39: 71-81, 2021
Kazuo Okamoto and Hiroshi Takayanagi
Osteoimmunology
Cold Spring Harbor Perspectives in Medicine, 9:1, 2019
Kazuo Okamoto and Hiroshi Takayanagi
Osteoimmunology
Genetics of Bone Biology and Skeletal Disease, Second Edition, 261-282, 2017 (ACADEMIC PRESS/ ELSEVIER)
Kazuo Okamoto, Tomoki Nakashima, Masahiro Shinohara, Takako Negishi-Koga, Noriko Komatsu, Asuka Terashima, Shinichiro Sawa, Takeshi Nitta and Hiroshi Takayanagi
Osteoimmunology: the conceptual framework unifying the immune and skeletal systems
Physiological Reviews, 97: 1295-1349, 2017
Kazuo Okamoto and Hiroshi Takayanagi
Potential molecular targets for suppressing Th17 development
Inflammation and Regeneration, 31: 354-360, 2011
Kazuo Okamoto and Hiroshi Takayanagi
Regulation of bone by the adaptive immune system in arthritis
Arthritis Research & Therapy, 13: 219, 2011
Kazuo Okamoto and Hiroshi Takayanagi
Osteoclasts and interleukin-17-producing helper T cells in rheumatoid arthritis
Arthritis: Pathophysiology, Prevention and Therapeutics, 75-89, 2011
Kazuo Okamoto and Hiroshi Takayanagi
Osteoclasts in arthritis and Th17 development
International Immunopharmacology, 11: 543-548, 2011