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Original papers

Yutaro Ando, Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Shizao Zang, Minglu Yan, Ryunosuke Muro, Kazutaka Nakamura, Masatsugu Komagamine, Noriko Komatsu, Kazuo Okamoto, Kenta Nakano, Tadashi Okamura, Akira Yamaguchi, Kazuyuki Ishihara, Hiroshi Takayanagi

The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis

International Journal of Oral Science. 16:18, 2024

 

Masatsugu Komagamine, Noriko Komatsu, Rui Ling, Kazuo Okamoto, Shi Tianshu, Kotaro Matsuda, Tsutomu Takeuchi, Yuko Kaneko and Hiroshi Takayanagi

Effect of JAK inhibitors on the three forms of bone damage in autoimmune arthritis: joint erosion, periarticular osteopenia, and systemic bone loss.

Inflammation and Regeneration. 43:44, 2023

 

Minglu Yan, Tsukasaki Masayuki, Ryunosuke Muro, Noriko Komatsu, Takeshi Nitta, Tadashi Okamura, Kazuo Okamoto, Yutaro Ando, and Kazutaka Nakamura Hiroshi Takayanagi

Identification of an intronic enhancer regulating RANKL expression in osteocytic cells

Bone Research, 11: 43, 2023

Minglu Yan, Noriko Komatsu, Ryunosuke Muro, Nam Huynh, Yoshihiko Tomofuji, Yukinori Okada, Hiroshi Suzuki, Hiroyuki Takaba, Riko Kitazawa, Sohei Kitazawa, Warunee Pluemsakunthai, Yuichi Mitsui, Takashi Satoh, Tadashi Okamura, Takeshi Nitta, Sin-Hyeog Im, Chan Johng Kim, George Kollias, Sakae Tanaka, Kazuo Okamoto, Masayuki Tsukasaki and Hiroshi Takayanagi.

ETS1 governs pathological tissue remodeling programs in disease-associated fibroblasts

Nature Immunology, 23: 1330-1341, 2022.

 

Takehito Ono, Ryosuke Denda, Yuta Tsukahara, Takashi Nakamura, Kazuo Okamoto, Hiroshi Takayanagi and Tomoki Nakashima.

Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1a signaling

Bone Research. 10:52. 2022.

 

Masayuki Tsukasaki, Noriko Komatsu, Takako Negishi-Koga, Nam Cong-Nhat Huynh, Ryunosuke Muro, Yutaro Ando, Yuka Seki, Asuka Terashima, Warunee Pluemsakunthai, Takeshi Nitta, Takashi Nakamura, Tomoki Nakashima, Shinsuke Ohba, Haruhiko Akiyama, Kazuo Okamoto, Roland Baron and Hiroshi Takayanagi.

Periosteal stem cells control growth plate stem cells during postnatal skeletal growth

Nature Communications, 13: 4166, 2022

 

Mikhail M Kostik, Maria A Makhova, Alexei S Maletin, Shamai M Magomedova, Lybov S Sorokina, Masayuki Tsukasaki, Kazuo Okamoto, Hiroshi Takayanagi, Dmitriy S Vasiliev, Darya I Kozlova, Alexander Yu Mushkin.

Cytokine profile in patients with chronic non-bacterial osteomyelitis, juvenile idiopathic arthritis, and insulin-dependent diabetes mellitus

Cytokine, 143: 155521, 2021

Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Kazuo Okamoto, Ryunosuke Muro, Asuka Terashima, Yoshitaka Kurikawa, Noriko Komatsu, Warunee Pluemsakunthai, Takeshi Nitta, Takaya Abe, Hiroshi Kiyonari, Tadashi Okamura, Mashito Sakai, Toshiya Matsukawa, Michihiro Matsumoto, Yasuhiro Kobayashi, Josef M. Penninger and Hiroshi Takayanagi

Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution

Nature Metabolism, 2: 1382-1390, 2020

 

Masayuki Tsukasaki, Tatsuo Asano, Ryunosuke Muro, Nam Cong-Nhat Huynh, Noriko Komatsu, Kazuo Okamoto, Kenta Nakano, Tadashi Okamura, Takeshi Nitta and Hiroshi Takayanagi

OPG production matters where it happened

Cell Reports, 32: 108124, 2020

 

Tatsuo Asano, Kazuo Okamoto*, Yuta Nakai, Masanori Tsutsumi, Ryunosuke Muro, Ayako Suematsu, Kyoko Hashimoto, Tadashi Okamura, Shogo Ehata, Takeshi Nitta and Hiroshi Takayanagi* (*: corresponding authors)

Soluble RANKL is physiologically dispensable but accelerates tumor metastasis to bone.

Nature Metabolism, 1: 868-875, 2019

 

Mikihito Hayashi, Tomoki Nakashima, Noriko Yoshimura, Kazuo Okamoto, Sakae Tanaka and Hiroshi Takayanagi

Autoregulation of osteocyte Sema3A orchestrates estrogen action and counteracts bone aging

Cell Metabolism, 29: 1-11, 2019

 

Yuta Nakai, Kazuo Okamoto*, Asuka Terashima, Shogo Ehata, Jun Nishida, Takeshi Imamura, Takashi Ono and Hiroshi Takayanagi* (*: corresponding authors)

Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis

Bone Research, 7: 1, 2019

 

Maia Inoue, Kazuo Okamoto, Asuka Terashima, Takeshi Nitta, Ryunosuke Muro, Takako Negishi-Koga, Toshio Kitamura, Tomoki Nakashima, and Hiroshi Takayanagi

Arginine methylation controls the strength of γc family cytokine signaling in T cell maintenance

Nature Immunology, 19: 1265-1276, 2018

 

Masayuki Tsukasaki, Noriko Komatsu, Kazuki Nagashima, Takeshi Nitta, Warunee Pluemsakunthai, Chisa Shukunami, Yoichiro Iwakura, Tomoki Nakashima, Kazuo Okamoto, and Hiroshi Takayanagi

Host defense against oral microbiota by bone-damaging T cells

Nature Communications, 9: 701, 2018

 

Masayuki Tsukasaki*, Koki Hamada*, Kazuo Okamoto, Kazuki Nagashima, Asuka Terashima, Noriko Komatsu, Stephanie Win, Tadashi Okamura, Takeshi Nitta, Hisataka Yasuda, Josef M. Penninger and Hiroshi Takayanagi *equally contributed

LOX fails to substitute for RANKL in osteoclastogenesis

Journal of Bone and Mineral Research, 32: 434-439, 2017

 

Asuka Terashima, Kazuo Okamoto, Tomoki Nakashima, Shizuo Akira, Koichi Ikuta and Hiroshi Takayanagi

Sepsis-induced osteoblast ablation causes immunodeficiency

Immunity, 44: 1434-43, 2016

 

Takehito Ono, Kazuo Okamoto, Tomoki Nakashima, Takeshi Nitta, Shohei Hori, Yoichiro Iwakura and Hiroshi Takayanagi

IL-17-producing γδT cells enhance bone regeneration

Nature Communications, 7: 10928, 2016

 

Matteo M. Guerrini, Kazuo Okamoto, Noriko Komatsu, Shinichiro Sawa, Lynett Danks, Josef M. Penninger, Tomoki Nakashima and Hiroshi Takayanagi

Inhibition of the TNF family cytokine RANKL prevents autoimmune inflammation in the central nervous system

Immunity, 43: 1174-85, 2015

 

Takako Negishi-Koga, Hans-Jürgen Gober, Eriko Sumiya, Noriko Komatsu, Kazuo Okamoto, Shinichiro Sawa, Ayako Suematsu, Tomomi Suda, Kojiro Sato, Toshiyuki Takai and Hiroshi Takayanagi

Immune complexes regulate bone metabolism through FcRg signaling

Nature Communications, 6: 6637, 2015

 

Yasunori Omata, Tetsuro Yasui, Jun Hirose, Naohiro Izawa, Yuuki Imai, Takumi Matsumoto, Hironari Masuda, Naoto Tokuyama, Shuichi Tsutsumi, Takanori Fujita, Hisataka Yasuda, Kazuo Okamoto, Hiroshi Takayanagi, Atsuhiko Hikita, Takeshi Imamura, Koichi Matsuo, Taku Saito, Yuho Kadono, Hiroyuki Aburatani, and Sakae Tanaka

Genome-wide comprehensive analysis reveals critical cooperation between Smad and c-Fos in RANKL-induced osteoclastogenesis

Journal of Bone and Mineral Research, 30:869-877, 2015

 

Noriko Komatsu, Kazuo Okamoto, Shinichiro Sawa, Tomoki Nakashima, Masatsugu Oh-hora, Tatsuhiko Kodama, Sakae Tanaka, Jeffrey A. Bluestone and Hiroshi Takayanagi

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.

Nature Medicine, 20: 62-68,2014

 

Jun-ichi Furusawa, Kazuyo Moro, Yasutaka Motomura, Kazuo Okamoto, Jinfang Zhu, Hiroshi Takayanagi, Masato Kubo and Shigeo Koyasu

Critical Role of p38 and GATA3 in Natural Helper Cell Function.

The Journal of Immunology, 191: 1818-26, 2013

 

Erik Idrus, Tomoki Nakashima, Ling Wang, Mikihito Hayashi, Kazuo Okamoto, Tatsuhiko Kodama, Nobuyuki Tanaka, Tadatsugu Taniguchi and Hiroshi Takayanagi

The Role of the BH3-only Protein Noxa in Bone Homeostasis

Biochemical and Biophysical Research Communications, 410: 620-625, 2011

 

Kazuo Okamoto, Yoshiko Iwai, Masatsugu Oh-hora, Masahiro Yamamoto, Tomohiro Morio, Kazuhiro Aoki, Keiichi Ohya, Anton M. Jetten, Shizuo Akira, Tatsushi Muta and Hiroshi Takayanagi

IκBζ regulates TH17 development by cooperating with ROR nuclear receptors

Nature, 464: 1381-1385, 2010

 

Masahiro Shinohara, Takako Koga, Kazuo Okamoto, Shinya Sakaguchi, Kimiko Arai, Hisataka Yasuda, Toshiyuki Takai, Tatsuhiko Kodama, Tomohiro Morio, Raif S. Geha, Daisuke Kitamura, Tomohiro Kurosaki, Wilfried Ellmeier and Hiroshi Takayanagi

Tyrosine Kinases Btk and Tec Regulate Osteoclast Differentiation by Linking RANK and ITAM Signals

Cell, 132: 794-806, 2008

 

Masataka Asagiri, Toshitake Hirai, Toshihiro Kunigami, Shunya Kamano, Hans-Jürgen Gober, Kazuo Okamoto, Keizo Nishikawa, Eicke Latz, Douglas T. Golenbock, Kazuhiro Aoki, Keiichi Ohya, Yuuki Imai, Yasuyuki Morishita, Kohei Miyazono, Shigeaki Kato, Paul Saftig and Hiroshi Takayanagi

Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis

Science, 319: 624-627, 2008

 

Kojiro Sato, Ayako Suematsu, Kazuo Okamoto, Akira Yamaguchi, Yasuyuki Morishita, Yuho Kadono, Sakae Tanaka, Tatsuhiko Kodama, Shizuo Akira, Yoichiro Iwakura, Daniel J. Cua and Hiroshi Takayanagi

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

Journal of Experimental Medicine 203: 2673-2682, 2006

 

Takuya Yamamoto, Miki Ebisuya, Fumito Ashida, Kazuo Okamoto, Shin Yonehara and Eisuke Nishida

Continuous ERK Activation Downregulates Anti-proliferative Genes throughout G1 Phase to Allow Cell Cycle Progression

Current Biology, 16: 1171-1182, 2006

 

Kazuo Okamoto, Jun-ichi Fujisawa, Michael Reth and Shin Yonehara

Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kB

Genes to Cells, 11: 177-191, 2006

 

Kozo Watanabe, Kazuo Okamoto and Shin Yonehara

Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP

Cell Death and Differentiation, 12: 10-18, 2005

Reviews

Kazuo Okamoto* and Hiroshi Takayanagi (*: corresponding authors)

Effect of T cells on bone

Bone. 168:116675, 2023.

 

Kazuo Okamoto

Role of RANKL in cancer development and metastasis

Journal of Bone and Mineral Metabolism, 39: 71-81, 2021

 

Kazuo Okamoto and Hiroshi Takayanagi

Osteoimmunology

Cold Spring Harbor Perspectives in Medicine, 9:1, 2019

Kazuo Okamoto and Hiroshi Takayanagi

Osteoimmunology

Genetics of Bone Biology and Skeletal Disease, Second Edition, 261-282, 2017 (ACADEMIC PRESS/ ELSEVIER)

 

Kazuo Okamoto, Tomoki Nakashima, Masahiro Shinohara, Takako Negishi-Koga, Noriko Komatsu, Asuka Terashima, Shinichiro Sawa, Takeshi Nitta and Hiroshi Takayanagi

Osteoimmunology: the conceptual framework unifying the immune and skeletal systems

Physiological Reviews, 97: 1295-1349, 2017

Kazuo Okamoto and Hiroshi Takayanagi

Potential molecular targets for suppressing Th17 development

Inflammation and Regeneration, 31: 354-360, 2011

 

Kazuo Okamoto and Hiroshi Takayanagi

Regulation of bone by the adaptive immune system in arthritis

Arthritis Research & Therapy, 13: 219, 2011

 

Kazuo Okamoto and Hiroshi Takayanagi

Osteoclasts and interleukin-17-producing helper T cells in rheumatoid arthritis

Arthritis: Pathophysiology, Prevention and Therapeutics, 75-89, 2011

 

Kazuo Okamoto and Hiroshi Takayanagi

Osteoclasts in arthritis and Th17 development

International Immunopharmacology, 11: 543-548, 2011

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